and Spontaneous Tumors
نویسنده
چکیده
The microscopic study of a variety of tumors, by means of cytological technics not ordinarily ap plied to such tissue (19), has led to the observation of spores and other fungal structures in all types of neoplasms examined. These structures were noted initially in the debris of tumors degenerating in response to chemotherapeutic agents; later, by means of special stains, they were studied in the intact tissue and found to be intracellular or even intranuclear. Attempts to isolate the organisms from tissue were successful in so many types of neoplasm, including human tumors and spon taneous tumors of the mouse, that we have become convinced that they must play some significant role—even if only a secondary one; and studies were undertaken in the hope of elucidating these relationships. The present paper deals with our general observations; the study of specific tumors will be reported later.
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